What we do

Research publications

2019 Research Publications

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  • Early vitrectomy in endophthalmitis. Paul R, Simunovic M, Dawkins R, Bhullar G, Essex R, Chang A, Allen P. In clinical and experimental ophthalmology 2019 Nov 1 (vol. 47, pp. 155-155). 111 river st, hoboken 07030-5774, nj usa: wiley.
  • Ultra-Widefield Fluorescein Angiography as a Biomarker for Response to Switch in Therapy in Persistent DME. Bahrami B, Hong T, Peto T, Chang A. Ophthalmic Surgery, Lasers and Imaging Retina. 2019 Dec 27;50(12):771-8.
  • Aflibercept for persistent diabetic macular oedema: 48 week outcomes. Bahrami B, Hong T, Schlub T, Chang A. Retina. 1 Jan 2019.
  • Pharmacotherapy of vitreomacular traction. Wan R, Hong T, Tariq Y, Chang A. Curr Pharm Des 2019.
  • Current Outcomes of Anti-VEGF Therapy in the Treatment of Macular Edema Secondary to Central Retinal Vein Occlusions: A Systematic Review and Meta-Analysis. Spooner K, Hong T, Fraser-Bell S, Chang A. Asia Pac J Ophthalmol (Phila). 2019 May-Jun;8(3):236-246.
  • Post‐surgical versus post‐intravitreal injection endophthalmitis: changing patterns in causative flora. Ong AP, Angbue Te N, Zagora SL, Symes RJ, Yates W, Chang AA, McCluskey PJ, Simunovic MP. Clinical & experimental ophthalmology. 2019 Jan;47(1):57-62.
  • Early pars plana vitrectomy for treatment of acute infective endophthalmitis. Ho IV, Fernandez-Sanz G, Levasseur S, Ting E, Liew G, Playfair J, Downie J, Gorbatov M, Hunyor AP, Chang AA. The Asia-Pacific Journal of Ophthalmology. 2019 Jan 1;8(1):3-7.
  • Saffron therapy for the treatment of mild/moderate age-related macular degeneration: a randomised clinical trial. Broadhead GK, Grigg JR, McCluskey P, Hong T, Schlub TE, Chang AA. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2019 Jan 28;257(1):31-40.
  • A meta‐analysis of patients with treatment‐resistant macular oedema secondary to retinal vein occlusions following switching to aflibercept. Spooner K, Hong T, Bahrami B, Chang A. Acta ophthalmologica. 2019 Feb;97(1):15-23.
  • Five-year outcomes of retinal vein occlusion treated with vascular endothelial growth factor inhibitors. Spooner K, Fraser-Bell S, Hong T, Chang AA. BMJ open ophthalmology. 2019 Mar 1;4(1):e000249.
2020 Research Publications

egulatory Requirements

  • Optical-coherence tomography angiography and ultrawide-field angiography findings in eyes with refractory macular edema secondary to retinal vein occlusion switched to aflibercept: A subanalysis from a 48-week prospective study. Spooner K, Fraser-Bell S, Hong T, Chang A. Taiwan J Ophthalmol. 2020
  • Brolucizumab: an evolution in treatment for neovascular age-related macular degeneration.
    Ong EL, Spooner K, Hong T, Chang A. Expert Review of Ophthalmology. 2020 Mar 3;15(2):71-81.
  • To Treat or Not to Treat: Management Options for Symptomatic Vitreous Floaters.
    Broadhead GK, Hong T, Chang AA. The Asia-Pacific Journal of Ophthalmology. 2020 Mar 1;9(2):96-103.
  • Effects of Switching to Aflibercept in Treatment Resistant Macular Edema Secondary to Retinal Vein Occlusion. Spooner K, Fraser-Bell S, Hong T, Chang A. Asia-Pacific Journal of Ophthalmology: January-February 2020 – Volume 9 – Issue 1 – p 48-53
  • Efficacy and Safety of Abicipar in Neovascular Age-Related Macular Degeneration: 52-Week Results of Phase 3 Randomized Controlled Study. Kunimoto D, Yoon YH, Wykoff CC, Chang A, Khurana RN, Maturi RK, Agostini H, Souied E, Chow DR, Lotery AJ, Ohji M. Ophthalmology. 2020 Apr 9.
  • Macular Atrophy Incidence and Progression in Eyes with Neovascular Age-Related Macular Degeneration Treated with VEGF Inhibitors Using a Treat-and-Extend or a Pro-Re-Nata Regimen. Four Year Results of the MANEX Study. Spooner KL, Fraser-Bell S, Cozzi M, Staurenghi G, Invernizzi A, Monteduro D, Munk MR, Hong T, Chang AA. Ophthalmology. 2020 Jun 13.
  • Does functional assessment predict everyday visual functioning? Visual function testing and quality of life in mild/moderate age-related macular degeneration. Broadhead GK, Hong T, Grigg JR, McCluskey P, Schlub TE, Spooner K, Chang AA. International Ophthalmology. 2020 Jul 14:1-9.
  • Prospective study of aflibercept for the treatment of persistent macular oedema secondary to retinal vein occlusions in eyes not responsive to long‐term treatment with bevacizumab or ranibizumab. Spooner K, Fraser-Bell S, Hong T, Chang A. Clinical & Experimental Ophthalmology. 2020 Jan;48(1):53-60.
  • Patient-reported outcomes from a phase IV study of aflibercept in patients with refractory retinal vein occlusions. Spooner K, Fraser-Bell S, Hong T, Chang A. Taiwan J Ophthalmol. 2020
  • Long-term Anti-Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration: The LATAR Study: Report 1: Ten-Year, Real-World Outcomes.
    Spooner K, Fraser-Bell S, Hong T, Phan L, Wong JG, Chang A. Ophthalmol Retina. 2021 Jun;5(6):511-518. doi: 10.1016/j.oret.2020.09.019. Epub 2020 Sep 29.
2021 Research Publications

Are You A Clinician With A Passion For Improved Outcomes?

  • Long-term outcomes of anti-VEGF treatment of retinal vein occlusion. Spooner KL, Fraser-Bell S, Hong T, Wong JG, Chang AA. Eye (Lond). 2021 Jun 11.
  • Efficacy and safety of brolucizumab versus aflibercept in eyes with polypoidal choroidal vasculopathy in Japanese participants of HAWK. Ogura Y, Jaffe GJ, Cheung CM, Kokame GT, Iida T, Takahashi K, Lee WK, Chang AA, Monés J, D’Souza D, Weissgerber G. British Journal of Ophthalmology. 2021 Jul 21.
  • Anti-inflammatory and neuroprotective properties of the corticosteroid fludrocortisone in retinal degeneration. Racic T, Chang A, Fernando N, Brandli A, Natoli R, Penfold P, Provis JM, Rutar M. Exp Eye Res. 2021 Sep 9:108765. doi: 10.1016/j.exer.2021.108765. Epub ahead of print. PMID: 34509498.
  • Early Residual Fluid-free Status and Long-term BCVA outcomes: A Treatment Agnostic, Post-hoc Analysis of Pooled HAWK and HARRIER Data. Jhaveri, C., Wykoff, C.C., Khanani, A.M., Eandi, C.M., Chang, A., Guruprasad, B., Gedif, K.A. and Singer, M., 2021. American Journal of Ophthalmology.
  • Treat-and-extend regimens for the management of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy: Consensus and recommendations from the Asia-Pacific Vitreo-Retina Society. Chaikitmongkol V, Sagong M, Lai TYY, Tan G.S, Fariza N, Ohji M, Mitchell P, Yang CH, Raumviboonsik P, Wong I, Sakamoto T, Rajendran A, Chen Y, Wong TY, Cheung CMG, Chang A, Koh A. APJO 2021 In press
  • Comparison between two multimodal imaging platforms: Nidek Mirante and Heidelberg Spectralis. Spooner K, Phan L, Cozzi M, Hong T, Staurenghi G, Chu E, Chang AA. Graefes Arch Clin Exp Ophthalmol. 2021 Jan 6. doi: 10.1007/s00417-020-05050-7. Epub ahead of print. PMID: 33409677.
  • Diet and risk of visual impairment: a review of dietary factors and risk of common causes of visual impairment. Broadhead GK, Hong T, Bahrami B, Flood V, Liew G, Chang AA. Nutr Rev. 2021 May 12;79(6):636-650.
  • Treat and extend paradigm in management of neovascular age-related macular degeneration: current practice and future directions. Bowditch E, Chu E, Hong T, Chang AA. Expert Review of Ophthalmology. 2021 May 26.
2022 Research Publications

We are an experienced team

  • Phase 1B study of the safety and tolerability of the mineralocorticoid fludrocortisone acetate in patients with geographical atrophy. Hong T, Chang A, Maddess T, Provis J, Penfold P. BMJ Open Ophthalmology 2022;0:e001032. doi:10.1136/bmjophth-2022-001032
  • Transketolase in human Müller cells is critical to resist light stress through the pentose phosphate and NRF2 pathways, Chen Y, Zhang T, Zeng S, Xu R, Jin K, Coorey NJ, Wang Y, Wang K, Lee S, Yam M, Zhu M, Chang A, Fan X, Zhang M, Du J, Gillies MC, Zhu L. Redox Biology, June 2022, 102379, ISSN 2213-2317,
  • Optical Coherence Tomography Classification Systems for Diabetic Macular Edema and Their Associations With Visual Outcome and Treatment Responses – An Updated Review
    Hui V ,Szeto S.K.H., Tang F, Yang D, Chen H, Lai T, Rong A, Zhang S, Zhao P, Ruamviboonsuk P, Lai CC, Chang A, Das D, Ohji M, Huang SS, Sivaprasad S, Wong TY, Lam DSC, Cheung CY. Asia-Pacific Journal of Ophthalmology: June 2022 – Volume 11 – Issue 3 – p 247-25
  • Visualisation of peripheral retinal degenerations and anomalies with ocular imaging.
    Cheung R, Ly A, Katalinic P, Coroneo MT, Chang A, Kalloniatis M, Madigan MC, Nivison-Smith L. Seminars in Ophthalmology. 2022 Mar 7. DOI: 10.1080/08820538.2022.2039222
  • Phase 3 Randomized Clinical Trials Of Faricimab For Diabetic Macular Edema: Study Design And Rationale. Eter N, Singh RP, Abreu F, Asik K, Basu K, Baumal C, Chang A, Csaky KG, Haskova Z, Lin H, Ruiz C Q, Ruamviboonsuk P, Silverman D, Wykoff CC, Willis JR. Yosemite And Rhine. Ophthalmology Science. 2022 Mar;2(1):100111.

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